Table 3 List of mutant peptides identified by COSMIC-based database
From: COSMIC-based mutation database enhances identification efficiency of HLA-I immunopeptidome
No | Peptide | Origin | Hyperscore | Length | Nucleic variant | Amino variant | Protein | Binding level | HLA allele | Elution rank % |
|---|---|---|---|---|---|---|---|---|---|---|
1 | RYSEYTEEF | COSMIC | 22.11 | 9 | c.1795G > A | p.A599T | MTMR6 | Strong | HLA-A*24:02 | 0.003 |
2 | RMPEAAPRV | COSMIC | 11.81 | 9 | c.215C > G | p.P72R | TP53 | Strong | HLA-A*02:01 | 0.084 |
3 | SLFDASHML | HepG2 COSMIC | 11.98 | 9 | c.242 T > C | p.V81A | AMT | Strong | HLA-A*02:01 | 0.007 |
4 | TVLSSRPVV | COSMIC | 13.06 | 9 | c.1574 T > C | p.I525T | ITGAL | Weak | HLA-B*51:08 | 1.487 |
5 | LSWHLPLLI | COSMIC | 18.14 | 9 | c.26G > A | p.R9H | IL2RB | Weak | HLA-C*16:02 | 1.029 |
6 | LNDLIVALS | COSMIC | 12.87 | 9 | c.1668C > A | p.F556L | NVL | None | – | – |
7 | KAYGSYEELAKDPN | COSMIC | 11.19 | 14 | c.197G > A | p.S66N | DHDH | None | – | – |
8 | DEAQNLTRD | COSMIC | 12.61 | 9 | c.2177G > A | p.G726D | DDX54 | None | – | – |
9 | HGELLEVNL | COSMIC | 14.11 | 9 | c.219C > A | p.D73E | PCDHA13 | None | – | – |
10 | LFLDAIHLT | COSMIC | 14.69 | 9 | c.2255C > T | p.P752L | BBX | None | – | – |
11 | DLLLVPTAGL | COSMIC | 18.93 | 10 | c.346 T > G | p.Y116D | PROM2 | None | – | – |
12 | GTLLSGAVGSLLL | COSMIC | 19.86 | 13 | c.508A > T | p.T170S | SLC17A9 | None | – | – |
13 | HMLIDLHFR | COSMIC | 12.86 | 9 | c.559A > T | p.M187L | FMR1 | None | – | – |
14 | QVQLLQQQ | COSMIC | 12.12 | 8 | c.593A > T | p.Q198L | TFAP4 | None | – | – |
15 | DSNRNLDLDSIIA | COSMIC | 23.42 | 13 | c.914A > G | p.N305S | KRT79 | None | – | – |
16 | QVQIGTHSPP | COSMIC | 12.92 | 10 | c.2125G > A | p.A709T | PHEX | None | – | – |