Fig. 4

Intercellular communication network atlas of 15 cell clusters. A. Heatmap showing the top 14 signals in the 15 cell clusters with the largest contribution of outgoing or incoming signals. B. Bar charts illustrating the quantity and intensity of intercellular communication. C. Chord diagrams of six signaling pathways showing complex interactions between cell populations. D. Heatmaps depicting network centrality scores for the six signaling. E–G. Bar graphs depicting ligand-receptor pairs mediating the communication of the MIF, SPP1, and ANGPTL signaling; dot plots of the dynamic expression changes of receptor-ligand pairs associated with the MIF, SPP1, and ANGPTL signaling in the pseudo temporal trajectory; violin plots depicting the differential expression of MIF, SPP1, and ANGPTL signaling L-R pair genes between tumor cells and epithelial cells (Mann–Whitney U test, ***p < 0.001). E.T + E indicating that the cluster consists of E.T cells and epithelial cells