Table 5 Different virus delivery systems and their advantages and disadvantages
From: Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Delivery system | Type of OVs | Advantage | Disadvantage |
|---|---|---|---|
hMSCs | AdV | The higher viral copies can be delivered, and increase the circulation of viral particles | Poor uptake of OVs by hMSCs |
NSCs | CRAd | NSCs promote CRAd penetration of the blood–brain barrier, and with robust tumor tropism | Poor infection of mouse tissues by human AdV |
Nanoparticle | AdV, MV, NDV | Nanoparticles have a high enhanced permeability and retention (EPR) effect, which is easier to penetrate into tumor tissues and the retention time is longer | Nanoparticles release drug effector substances that are easily degraded |
Hydrogel | CRAd | The stronger cytotoxicity to cancer cells and long-term antitumor therapeutic effects | Hydrogel may lead to increased toxicity and also damage surrounding cells |