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Table 3 Main genetically engineered virus strains

From: Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer

Oncolytic virus

Viral structures

Critical pathway of specific infections in tumors

Partial genetically engineered oncolytic virus strains

References

Herpes simplex virus

Linear double-stranded DNA virus

Interferon signaling pathway

NV1020, G207, HF-10, HSV-1716, T-VEC, G47∆, M032, RP1, RP2, R36166, DM33, C134

[20, 21, 25]

Newcastle disease virus

Single-stranded RNA virus

Interferon signaling pathway

Lasota, Anhinga, Mukteswar

[28,29,30,31]

Vaccinia virus

Linear double-stranded DNA virus

EGFR-Ras signaling pathway

Wyeth, Lister, Copenhagen, Western Reserve, Tian Tan, Modified, Vaccinia Ankar

[41, 42]

Measles virus

Single-stranded RNA virus

Density differences of CD46, SLAM and Nectin-4 receptors

MV-CEA, MV-NIS

[39]

Adenovirus

Linear double-stranded DNA virus

Rb and p53 cell signaling pathway

H101, ONYX-105, DNX-2401, LOAD703, VCN-01, OBP-301, ONCOS-102

[44, 45, 95]