Fig. 2

Differential analysis between UTUC and BC. A Identification of differential genes between UTUC and BC. B Gene Ontology (GO) analysis of UTUC-specific differential genes. C KEGG pathway analysis of UTUC-specific differential genes. D Screening of UTUC-specific KEGG pathways (those not ranked in the top in BLCA differential gene KEGG but ranked in the top in UTUC differential gene KEGG). E Differential immune infiltration analysis between UTUC and BC. F-I Further GSEA screening of UTUC-specific pathways: Proteoglycans pathway, cell adhesion molecules pathway, and extracellular matrix molecules pathway show significant differences in three groups of UTUC transcriptome data (|NES|> 1). (p ≤ 0.01 as **, p ≤ 0.001 as ***, p ≤ 0.0001 as ****)