Fig. 6From: Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiologyPathophysiological mechanisms of 5-HTergic hyperactivity in ME/CFS. High 5-HTergic innervation causes central fatigue and ME/CFS-representative features, including dysfunction of hypothalamic–pituitary–adrenal (HPA) and autonomic nervous system (ANS) via desensitization of 5-HT1A receptorBack to article page