Fig. 3

5-fluorouracil and doxorubicin induce similar changes in differentiation and EMT genes in individual MCF7 PDSs. A, B Drug fingerprints of patient-derived scaffold (PDS) cultures obtained subtracting the untreated gene expression value from the treated value for each gene after treatment with 5-fluorouracil (5-FU) (A) or doxorubicin (DOX) (B). The largest variation in gene expression changes between individual PDSs is indicated by interquartile range > 1.5 (IQR). C, D, E Pearson correlation analyses between the drug fingerprints for each gene in the individual PDSs treated with 5-FU (C), DOX (D) or 5-FU versus DOX (E). (P-values for each analysis are detailed in Additional file 2: Tables S3–5)