Fig. 2

Gene expression changes in MCF7 cancer cells grown in PDSs treated with chemotherapy. A RNA yield (ng/µl) of the lysates from patient-derived scaffold (PDS) cultures for controls (untreated), 5-fluorouracil (5-FU) or doxorubicin (DOX) treatment. (****P < 0.0001). B Scatter plots showing gene expression levels of untreated and treated PDS cultures, relative to untreated 2D culture gene expression and stablished as 0 value (*P < 0.05, ** P < 0.01. ***P < 0.001. ****P < 0.0001). Gene families for the selected genes are indicated