Fig. 7

PIGT overexpression promotes cell metastasis by activating GLUT1. BIU-87 cells were transduced with control lentivirus (vector), PIGT overexpression lentivirus (oePIGT) and/or GLUT1 shRNA lentivirus, and the A, B cell migration and C, D invasion were measured. BIU-87-vector, BIU-87-oePIGT and/or GLUT1 shRNA lentivirus were given to mice. E Histology of metastasized lungs of mice (scale bar, 100 μm). F Quantification of the number of metastatic nodules (6 mice in each group). G Survival of mice (20 mice in each group). **P < 0.01, ***P < 0.001 vs shNC + Vector. ^###P < 0.001 vs shNC + oePIGT