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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway

Fig. 9

Bulk-RNA sequencing combined with single-cell analysis revealed key downstream pathways that enhanced migration and invasion of M2 macrophages. a In vitro co-culture pattern diagram. b Heat map showing differential expressed gene expression of M2 macrophages after secondary sequencing in Zileuton-CM or Con-CM co-culture. c GO/KEGG analysis shown by bubble plot. d Chord plot of pathway-specific GO/KEGG analysis. e GSEA analysis between high and low ALOX5 expression groups in TCGA-CHOL dataset. f Macrophages were highlighted in UMAP plot. g Volcano plot showed differentially expressed genes between tumor and normal samples in macrophage subsets. h Network diagram showing GO/KEGG analysis of differentially expressed genes in macrophage subsets

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Journal of Translational Medicine

ISSN: 1479-5876

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