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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway

Fig. 5

Evaluation of the expression level of ALOX5 in tissue samples and cell lines. a The heatmap showed the expression of 120 lipid metabolism-related genes with the most significant fold changes. b, c Violin plots showed significant upregulation of ALOX5 expression level in EMBI and TCGA databases. d Immunohistochemical image showing ALOX5 expression and localization in ICC and adjacent normal tissues. e Dot plot showing the relative expression levels of ALOX5 mRNA in 28 pairs of ICC patient tissues. f Histogram demonstrated ALOX5 RNA expression levels in 6 cell lines (H69: normal bile duct epithelial cell line; HUCCT1, RBE, QBC-939, HCCC-9810, CCLP-1: ICC cell lines). g WB showed the protein expression levels of ALOX5 in 6 cell lines. (*: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001)

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Journal of Translational Medicine

ISSN: 1479-5876

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