Fig. 13From: ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathwaySchematic diagram of this study. Upregulated ALOX5 in ICC cells promotes M2-TAM infiltration through LTB4/BLT1/2/PI3K/AKT axis. LTB4 enters TME from ICC cells, binds to M2 macrophage surface receptor BLT1/BLT2, activates PI3K pathway and recruits M2 macrophagesBack to article page