Fig. 11

In vivo translational efficacy of Zileuton combined with PLX3397. a Pattern diagram. b Tumor images showing tumor size in each group. c Violin diagram demonstrated the change of tumor volume in different treatment groups. d Immunohistochemical images showing ALOX5 protein expression levels in each group. e Immunofluorescence staining images showing the intensity and density of ALOX5 and CD163 in each group. f Gating strategy of M2 macrophages in tumor tissues of four groups (Markers: CD11b, F4/80: macrophages; CD163: M2 macrophages) g Bar chart showing the infiltration ratio of M2 macrophages in tumor tissues of the four groups (CD11b + F4/80 + CD163 + cells/ living cells). (*: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001)