Fig. 10

LTB4 activates PI3K pathway through BLT1/BLT2 to promote migration and invasion of M2 macrophages. a Transwell images showing the effect of addition of LTB4 on M2 macrophage migration and invasion in the presence of BLT1 or BLT2 inhibitors (derived from THP-1). b WB images demonstrating the expression of PI3K pathway proteins at different time after the addition of LTB4 to M2 macrophages derived from THP-1. c WB images showing expression of PI3K pathway proteins after addition of BLT1 and BLT2 inhibitors after addition of LTB4 to M2 macrophages derived from THP-1. d Transwell images demonstrating the effect of LTB4 addition on the migration and invasion of M2 macrophages (derived from THP-1) in the presence of PI3K, AKT, mTOR inhibitors. e Transwell images showing the effect of addition of LTB4 on M2 macrophage migration and invasion in the presence of BLT1 or BLT2 inhibitors (derived from RAW264.7). f WB images demonstrating the expression of PI3K pathway proteins at different time after the addition of LTB4 to M2 macrophages derived from RAW264.7. g WB images showing expression of PI3K pathway proteins after addition of BLT1 and BLT2 inhibitors after addition of LTB4 to M2 macrophages derived from RAW264.7. h Transwell images demonstrating the effect of LTB4 addition on the migration and invasion of M2 macrophages (derived from RAW264.7) in the presence of PI3K, AKT, mTOR inhibitors