Fig. 4
An overview of the potential effects of NQO1 alterations on the pathophysiology of various neurological disorders. Specific impacts of increased and decreased NQO1 values in each disease are outlined. The changes of NQO1 expression and function may contribute to the pathophysiology of various neurological disorders by affecting the neural tissues to counteract oxidative stress and maintain redox homeostasis. This could potentially lead to the alterations in susceptibility to neurodegeneration and neuroinflammation. The functions of NQO1 changes appear diverse and sometimes conflicting [113,114,115,116]