Fig. 3

Dysregulation of the miR-192-Rictor-p53-miR-192 axis during hepatocarcinogenesis. A Morphology, H&E staining, Masson staining, and immunohistochemical staining changes of p53 and Rictor in liver tissues of rat cancer models at different stages: normal liver (NL), liver fibrosis (LF), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). B, C Comparison of protein expression profiles of Rictor and mTOR in liver tissues of rat models (B) and clinical patients (C) at different stages of hepatocarcinogenesis by western blotting and quantified via densitometric analysis (n = 6 for NL, LF, and LC each; three representatives were shown in each group; n = 5 for HCCs and background liver (BL) tissues). H&E: magnification × 100. IHC staining: magnification × 400. *P < 0.05; **P < 0.01; ns not significant