Fig. 1

Erbin deficiency aggravated inflammatory response and organ injuries and deteriorated prognosis of sepsis. A Erbin^−/− mice and WT mice were subjected to CLP procedure and euthanasia of mice after CLP 6 h, 24 h, and 48h. The serum TNF-α, IL-6, IL-1β, HMGB1, and IL-10 levels were measured. B, C Histopathologic changes in the liver tissue, serum AST, and ALT levels were detected after CLP. D–H Histopathologic changes and the injury score of lung tissue, the wet/dry ratio, the protein concentration, and the PMN/total cells in BALF were measured. I The survival rates of WT and Erbin^−/− mice subjected to CLP were observed. J BMDMs were treated with MDP (6 h), and the TNF-α, IL-6, IL-1β, HMGB1, and IL-10 levels were measured in the supernatant of Erbin^fl/fl and Erbin^{fl/fl/Lyz2−cre} BMDMs. Each group had 10 mice. The data are representative of 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 from ANOVA followed by Tukey’s post hoc test