Fig. 1

Ferroptosis is stimulated in kidney stone mice, and ferroptosis inhibition mitigates Gly-induced kidney injury. A Diagram of mouse moulding. B Effects of Lip-1 on bodyweight (n = 6). C H&E, Von-Kossa, and TUNEL staining (n = 6). D MDA, GSH, and Fe2 + levels (n = 6). E Serum BUN and Cr levels (n = 6). F GO and KEGG enrichment analyses of DEGs between the Gly and control groups (n = 3). G Immunofluorescence of SLC7A11, GPX4, and ACSL4 in vivo (n = 6). H Western blotting analysis of SLC7A11, GPX4, ACSL4 and PTGS2. Scale bar = 50 µm. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the control group; ^#P < 0.05 and ^##P < 0.01 compared with the Gly group