3D MR fingerprinting-derived myelin water fraction characterizing brain development and leukodystrophy

Table 5 Comparison of regression models assessing the relationships between age and myelin water fraction

Brain region	Second-order regression			Third-order regression			Second- vs Third-order regression
Brain region	Adjusted R²	RMSE	P value	Adjusted R²	RMSE	P Value	P value
Frontal white matter	0.90	0.04	< 0.001	0.94	0.03	< 0.001	< 0.001
Parietal white matter	0.83	0.06	< 0.001	0.85	0.06	< 0.001	0.002
Occipital white matter	0.81	0.07	< 0.001	0.84	0.06	< 0.001	< 0.001
Posterior limb of the internal capsule	0.83	0.05	< 0.001	0.90	0.03	< 0.001	< 0.001
Genu of the corpus callosum	0.86	0.08	< 0.001	0.86	0.08	< 0.001	0.04
Splenium of the corpus callosum	0.68	0.11	< 0.001	0.69	0.10	< 0.001	< 0.001
Caudate	0.64	0.01	< 0.001	0.65	0.01	< 0.001	0.19
Putamen	0.70	0.02	< 0.001	0.70	0.02	< 0.001	0.88
Thalamus	0.83	0.02	< 0.001	0.83	0.02	< 0.001	0.39
Cortex	0.42	0.02	< 0.001	0.44	0.02	< 0.001	0.06

ISSN: 1479-5876