3D MR fingerprinting-derived myelin water fraction characterizing brain development and leukodystrophy

Table 2 Comparison of megalencephalic leukoencephalopathy subcortical cyst 1 wild type and knock-out mice

Parameter	MLC1 WT	MLC1 KO	P value
Myelin water fraction
Corpus callosum	0.20 [0.03]	0.13 [0.04]	< 0.001
Cortex	0.12 [0.02]	0.06 [0.03]	< 0.001
PLP (%)
Corpus callosum	57 [50]	31 [22]	0.03
Cortex	86 [74]	42 [62]	0.16

Data are presented as medians with IQRs in brackets and ranges in parentheses or numbers of mice with percentages in parentheses
MLC1 = megalencephalic leukoencephalopathy with subcortical cyst 1, WT = wild type, KO = knock-out, PLP = anti-proteolipid protein immunoreactive area

ISSN: 1479-5876