Fig. 4

Comparison of myelin water fraction (MWF) and proteolipid protein (PLP) immunoreactive area values between leukodystrophy and control mice. Both the corpus callosum and cortex showed a difference in MWF values between MLC1 WT and KO mice (A). PLP immunoreactive area values was differed between MLC1 WT and KO mice in the corpus callous but not in the cortex (B). Representative PLP immunoreactive staining images and MWF maps of 13-month-old MLC1 WT and MLC1 KO mice (C). An asterisk (*) indicates a P-value smaller than 0.05