Fig. 2

The common differentially expressed genes between SARS-CoV-2 infection and cardiovascular diseases. Volcano plot of DEGs in the SARS-CoV-2-related GSE156754 dataset (A) and cardiovascular diseases-related GSE84796 dataset (B). Red dots represent up-regulated DEGs, blue dots represent down-regulated DEGs, and gray dots represent genes that were not significantly different between the two groups. Common up-regulated (C) and down-regulated (D) DEGs in the GSE156754 dataset (blue) and GSE84796 dataset (red) were represented by venn diagrams. E–S Expression of potential receptors or co-factors for SARS-CoV-2 entry in the cardiovascular diseases-related GSE84796 dataset. See also Supplementary methods in Additional file 1 for more information on these factors. CVD, cardiovascular disease. *P < 0.05; ***P < 0.001; ****P < 0.0001; ns, no significance