Fig. 6
Visual function detected by electroretinogram (ERG) in different groups of RCS rats after subretinal cell injection. A Representative dark-adapted ERG performance at 0.01, 3.0, and 10.0 cd s/m2 intensities for different groups of RCS rats at 4 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. The higher the amplitude of the wave is, the better the visual function is. B The average amplitude of scotopic b waves at 0.01, 3.0, and 10.0 cd·s/m2 intensities for RCS rats in different groups at 4 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. RCS rats subjected to four kinds of hMSCs or hiPSC-RPE cells transplantation showed a significant higher amplitude of the wave at 4 weeks post-injection. C Line graph of the average amplitude of scotopic b wave at 0.01, 3.0, and 10.0 cd s/m2 intensities for RCS rats in different groups at 4 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. D Representative dark-adapted ERG performance at 0.01, 3.0, and 10.0 cd s/m2 intensities for RCS rats in different groups at 8 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. E The average amplitude of scotopic b waves at 0.01, 3.0, and 10.0 cd s/m2 intensities for RCS rats in different groups at 8 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. Only RCS rats subjected to hiPSC-RPE cells transplantation showed a significant higher amplitude of the wave at 8 weeks post-injection. F Line graph of the average amplitude of scotopic b wave at 0.01, 3.0, and 10.0 cd s/m2 intensities for RCS rats in different groups at 8 weeks post-injection: non-cell injection (NONIJ, age-matched control), PBS injection, and cell injection of hDPSCs, hADSCs, hAFSCs, hBMSCs, hiPSCs, and hiPSC-RPE cells. *p < 0.05; “ns”: the difference was not statistically significant