Fig. 4

Visual function of RCS rats detected by light–dark box (LDB) testing of groups subjected to subretinal injection of different cells. A Schematic of the bright chamber and dark chamber in the LDB in which the RCS rats were placed under natural light condition. B Heatmap visualization of the locations of the RCS rats in different groups: non-cell injection (NONIJ, age-matched control) (i), PBS injection (ii), and cell injection of hDPSCs (iii), hADSCs (iv), hAFSCs (v), hBMSCs (vi), hiPSCs (vii), and hiPSC-RPE cells (viii), which revealed a higher frequency of the position of rats by red color, and a lower frequency by more of a blue color. C Duration (left figure) and percentage of time (right figure) for which the RCS rats were located in the bright chamber, showing rats that were subjected to subretinal transplantation and rats that were not injected with cells or PBS. D Duration for which the RCS rats were located in the dark chamber, showing rats that were subjected to subretinal transplantation and rats that were not injected with cells or PBS