Fig. 5
a. Measurement of oxidative stress in retinal tissue (red fluorescence). The ethidium bromide appears in higher level when superoxide anion produces more,especially in inner and RPE layers,leading to a stronger red fluorescence. b. Dihydroethidium (DHE) quantity in retinal tissues of mice in four groups. Data are represented as the mean ± standard deviation ***p < 0.001, ****p < 0.0001.HFD, high-fat diet; DM, high-fat diet + diabetes mellitus control; DMSO, high-fat diet + diabetes mellitus + dimethyl sulfoxide negative control; AdipoRon, high-fat diet + diabetes mellitus + AdipoRon