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Fig. 10 | Journal of Translational Medicine

Fig. 10

From: Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway

Fig. 10

a. Quantitative analysis of mRNA expression of AdipoR1 with different treatments. b. Changes in the expression of AdipoR1 pathway in Müller glia. Upregulation of AdipoR1 promoted the phosphorylation of the downstream AMPK/ACC and this effect was reversed by the AdipoR1-specific siRNA. ACC and AMPKα are the total proteins, and p-AMPK and p-ACC expression levels are represented by p-AMPK/AMPKα and p-ACC/ACC. c. Strips quantified using Image J software. The results are shown as mean ± standard deviation, *p < 0.05, **p < 0.01, *** p < 0.001. c. The different expressions of cleaved-caspase 3 among groups. Strips quantified using Image J software. The results were shown as mean ± standard deviation, **p < 0.01. ACC, acetyl CoA carboxylase; AMPK, 5ʹ adenosine monophosphate-activated protein kinase; AdipoR1, adioponectin receptor 1

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