Table 1 Summary of PK parameters for SPESN38-5
From: Single protein encapsulated SN38 for tumor-targeting treatment
|  | Cmax (ng/mL) | AUC0-24 h (ng × h/mL) | AUC0-∞ (ng × h/mL) | T1/2 (h) | CL/F L/h/kg) | CL (mL/h/kg) |
|---|---|---|---|---|---|---|
Single PO dose of SPESN38-5 (250Â mg/kg) | ||||||
 SN38 | 2.65 | 17.4 | 21.5 | 11.3 | 11,619 | – |
 SN38-G | 216.33 | 2312.1 | 2558.8 | 6.9 | – | – |
Single IV dose of SPESN38-5 (55Â mg/kg) | ||||||
 SN38 | 4883.33 | 6852.3 | 7377.6 | 6.9 | – | 7455 |
 SN38-G | 3123.33 | 13,931.8 | 15,794.8 | 7.6 | – | – |