Fig. 9
From: Single protein encapsulated SN38 for tumor-targeting treatment
Photographic images of tumors and hearts and Immunohistochemical staining (ICS) images for SPESN38-8. A Photographic images of tumors and hearts of each group at the end of experiments. Top, control groups on Day 9 when mice were euthanized due to fast tumor growth; Middle, DOX group on Day 9 when mice were euthanized due to severe toxicity, Bottom, SPEDSN38-8 group on Day 21, having six mice with no tumors or scar tissues without tumor cells, B Immunohistochemical staining images (40X) of paraffin-embedded tumor tissues (SK-LMS-1) sections for H & E, Ki67 and cleaved/active caspase 3 for tumor tissues for control group (left panel) and tumor tissue from SPESN38-8 treatment group (middle panel) and scar tissue without cancer cell from SPESN38-8 treatment group (right panel)