Fig. 3

Mouse BW changes vs days after treatment for SPESN38-5 on Day 1, A PO route at 250 mg/kg; B PO route at 200 mg/kg; C IV route at 55 mg/kg; D IV route at 50 mg/kg; E IV route at 45 mg/kg; F IV route at 35 mg/kg. The experiments at high doses were done with 2 mice/group to map the MTD range. At near MTD doses, 4 mice/group were used