Fig. 1
From: Single protein encapsulated SN38 for tumor-targeting treatment
Computer docking images of SPESN38 complexes using UCSF Chimera and AutoDock Vina. A SPESN38-5, B SPESN38-8. The SN38-HSA binding Gibbs free energy (ΔGo) at 8 docking sites was calculated to be − 9.5, − 9.1, − 8.6, − 7.7, − 7.7, − 7.6, − 7.5, and − 7,3 kcal/mol, corresponding to Kd values of 0.12–4.8 µM. C SN38 binding site 1, ΔGo = − 9.5 kcal/mol, Kd = 0.12 µM, D SN38 binding site 8, ΔGo = − 7.3 kcal/mol, Kd = 4.8 µM