From: The expanding Pandora’s toolbox of CD8+T cell: from transcriptional control to metabolic firing
TFs | Function | Refs. |
---|---|---|
T-bet | Affect CD8+ T cells fate; promote INF-γ expression; depress IL-17 production; interaction with mTOR and IL-12 | |
Runx3 | CTL proliferation; granzyme expression; interaction with T-bet and Eomes; | |
Sox9 | Negatively regulated CD8+ T cells | [158] |
NFAT | Inhibition the production of cytokine | [159] |
Eomes | Affect CD8 + T cells fate; the homeostasis of CD8+ T cells; IFN-α production; cytotoxicity; granzyme and perforin production; repress IL-17 and IL-12; interaction with mTOR | |
c-Myc | The homeostatic proliferation of memory CD8+ T cells | [161] |
Blimp-1 | The homeostasis of CD8+ T cells; cytotoxicity; interaction with IL-2 | |
Bcl-6 | The generation and maintenance of memory CD8+ T cells | [164] |
NF-κB | The generation and maintenance of memory CD8 + T cells; cytokine production | [165] |
Notch | CD8+ T cells proliferation; INF-γ expression; expression of eomesodermin, perforin, and granzyme B | |
STAT1/4 | Cytotoxicity generation and promote INF-γ expression |