Circulating small extracellular vesicles microRNAs plus CA-125 for treatment stratification in advanced ovarian cancer

Table 1 Performance of CA-125, 4 miRNAs, 4-miRNA panel, and 4-miRNA combined with CA-125 for predicting residual disease

Biomarker	Performance	Discovery set (n = 30)	Validation set (n = 154)
miR-320a-3p	Sensitivity	100	81.6
	Specificity	53.3	62.7
	PPV	65.2	80.0
	NPV	100	72.4
	AUC	75.6	77.2
miR-378a-3p	Sensitivity	66.7	87.4
	Specificity	80.0	50.7
	PPV	76.9	69.7
	NPV	70.6	75.6
	AUC	74.7	75.1
miR-1307-3p	Sensitivity	66.7	57.5
	Specificity	86.7	77.6
	PPV	76.9	76.1
	NPV	70.6	58.6
	AUC	77.6	68.2
let-7d-3p	Sensitivity	73.3	78.2
	Specificity	66.7	65.7
	PPV	68.8	74.2
	NPV	71.4	67.7
	AUC	69.3	78.4
4-miRNA panel	Sensitivity	93.3	83.9
	Specificity	93.3	85.1
	PPV	87.5	88.0
	NPV	92.9	80.3
	AUC	96.9	84.5
CA-125	Sensitivity	93.3	82.8
	Specificity	40.0	56.7
	PPV	50.0	70.6
	NPV	83.3	71.2
	AUC	66.2	72.3
CA-125 + 4-miRNA panel	Sensitivity	93.3	89.7
	Specificity	100.0	91.0
	PPV	100.0	92.6
	NPV	93.8	87.1
	AUC	97.3	90.3

The sensitivity, specificity, PPV positive predictive value, NPV negative predictive value and area under the curve (AUC) are shown as % (simple counts)

ISSN: 1479-5876