Fig. 3

Plasma sEVs derived miRNA profile in AOC patients A: Volcano plot showed all DEMs between non-R0 (n = 20) and R0 (n = 17) groups in small RNA sequencing. The red and blue represented the up-regulated and down-regulated DEMs, respectively. (|log2(FC)|> 1, P < 0.05); The table summarized the numbers of DEMs defined by different P values. B: A heatmap of 51 DEMs expressions in miRNA-seq data. C: Principal component analysis of 51 DEMs expressions between non-R0 and R0 groups. miRNA microRNA, sEVs small extracellular vesicles, AOC advanced ovarian cancer, DEMs differentially expressed miRNAs, R0 advanced ovarian cancer with no residual disease, non-R0 advanced ovarian cancer with any residual disease