Fig. 2
From: Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Therapeutic effects of NMN on heart and lung injury in septic mice. After an hour of FIP (3 g feces/kg body weight), mice received a single dose of NMN (500 mg/kg, i.p.) or vehicle. Six hours after FIP, myocardial function (A and B), caspase-3 activity (C), MPO activity (D), ROS production (E) and MDA level (F) were determined in the heart. G Pulmonary vascular permeability was assessed by Evans blue assay. ROS production (H), MDA level (I), caspase-3 activity (J) and MPO activity (K) were determined in lung tissues. L Lung tissues were fixed, embedded and sectioned. H&E staining was performed. A representative microphotograph for H&E staining from 6 lung samples is presented. Data are mean ± SD, n = 8 mice in each group. *P < 0.05 vs saline + vehicle and #P < 0.05 vs feces + vehicle (One-way ANOVA followed by Newman–Keuls test)