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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Fig. 7

Inhibition of ERK signaling inhibited the activation of the NLRP3 inflammasome. A Western blot of p-ERK of TCMK-1 cells induced by PD98059, TGF-β + C3a, and TGF-β + C3a + PD98059. B Quantitative analysis of p-ERK. C Western blot of NLRP3 and Caspase-1–20 of TCMK-1 cells induced by PD98059, TGF-β + C3a, and TGF-β + C3a + PD98059. D Quantitative analysis of NLRP3. E Quantitative analysis of Caspase-1–20. F ELISA of IL-1β of TCMK-1 cells induced by PD98059, TGF-β + C3a, and TGF-β + C3a + PD98059. **P < 0.01; NS, No significance

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Journal of Translational Medicine

ISSN: 1479-5876

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