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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Fig. 6

Inhibition of the NLRP3 Inflammasome alleviated EMT but didn’t affect the expression of C3aR. A Western blot of C3aR of TCMK-1 cells induced by MCC950, TGF-β + C3a, and TGF-β + C3a + MCC950. B Quantitative analysis of C3aR. C Immunofluorescent staining of α-SMA of TCMK-1 cells induced by MCC950, TGF-β + C3a, and TGF-β + C3a + MCC950. D α-SMA-positive area. E Immunofluorescent staining of ZO-1 of TCMK-1 cells induced by MCC950, TGF-β + C3a, and TGF-β + C3a + MCC950. F ZO-1-positive area. Scale bar:50 μm.**P < 0.01; NS, No significance

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Journal of Translational Medicine

ISSN: 1479-5876

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