Skip to main content
Fig. 4 | Journal of Translational Medicine

Fig. 4

From: C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Fig. 4

Inhibition of C3aR attenuated the activation of the NLRP3 inflammasome. A Western blot of NLRP3 and Caspase-1–20 of TCMK-1 cells induced by C3aRa, TGF-β + C3a, and TGF-β + C3a + C3aRa. B Quantitative analysis of NLRP3. C Quantitative analysis of Caspase-1–20. D ELISA of IL-1β of TCMK-1 cells induced by C3aRa, TGF-β + C3a, and TGF-β + C3a + C3aRa. E IL-1β immunohistochemistry of kidney sections of WT mice (sham operation/UUO) and C3aR KO mice (sham operation/UUO). F IL-1β-positive area. Scale bar:25 μm.**P < 0.01; NS, No significance

Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us