Fig. 8

CoQ10@TNPs reduced apoptosis and inflammatory responses in cardiac grafts. A, B TUNEL staining is indicative of apoptotic cardiomyocytes in the transplanted heart. C Western blotting was employed to evaluate the protein levels of Bax, Bcl-2, and C-caspase-3. D–F Statistics of Bax, Bcl-2, and C-caspase-3 expression. G, H Immunofluorescence staining of CD11b and Ly6G in cardiac grafts. I, J Statistics of CD11b and Ly6G in cardiac grafts. K‒M The expression of IL-6, MCP-1, and TNF-α was estimated by qPCR in cardiac grafts. Data are represented as the mean ± SD (n = 5). ns: no significance; *p < 0.05; **p < 0.01; ***p < 0.001