Fig. 2

The role of EZH1/2 alteration in ICI therapy. Kaplan–Meier survival analysis comparing overall survival between EZH1/2 alteration and wild-type patients in the ICI treatment, A discovery cohort and B validation cohort. Kaplan–Meier survival analysis comparing, C overall survival and D progression-free survival between EZH1/2 alteration and wild-type patients in the non-ICI treatment cohort. Comparison of the TMB between the EZH1/2 alteration and wild-type groups in the ICI treatment, E discovery and F validation cohorts and G non-ICI treatment cohort. H Comparison of alteration event frequency associated with DDR pathway between EZH1/2 alteration and wild-type patients in the TCGA pan‑cancer cohort. ICI, immune checkpoint inhibitor; HR, hazard ratio; CI, confidence interval; TMB, tumor mutation burden; FA, Fanconi anemia; HRR, homologous recombination repair; NHEJ, nonhomologous end-joining; BER, base excision repair; DR, direct repair; MMR, mismatch repair; NER, nucleotide excision repair; TLS, translesion synthesis; DDR, DNA damage response; TCGA, The Cancer Genome Atlas