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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs

Fig. 2

Multi-Fluorescence circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with lung cancer: single-tumor-biomarker SE-iFISH (five/six-channel): nucleus (blue), CD45 (red), CD31 (green/yellow), CK18 (green/yellow), vimentin (cyan) and CEP8 (orange). A CTCs and CTECs with multiple markers in different sizes. A-a DAPI+/CD45-/CK18-/CD31-/VIM-/CEP8 small triploid CTC with adjacent WBCs (red arrows). A-b DAPI+/CD45-/CD31-/CK18+/CEP8 small diploid CTC. A-c.DAPI+/CD45-/CK18-/CD31-/VIM-/CEP8 large multiploid CTC with adjacent WBC (red arrow). A-d DAPI+/CD45-/CD31+/CK18-/CEP8 large multiploid CTEC. A-e DAPI+/CD45-/CD31+/CK18+/CEP8 small multiploid CTEC B Vimentin+ Mesenchymal cells from patients with lung squamous cell carcinoma. B-a DAPI+/CD45-/CK18-/CD31-/VIM+/CEP8 diploid mesenchymal cell. B-b DAPI+/CD45-/CK18-/CD31+/VIM+/CEP8 diploid mesenchymal cell. C. Circulating tumor microemboli (CTM) from patients with squamous cell carcinoma with adjacent WBCs (red arrows). Bars: 5μm

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Journal of Translational Medicine

ISSN: 1479-5876

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