Fig. 7
From: Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche
iNOS deficiency altered gluconeogenesis and the adaptive immune response in the ileum transcriptome. A Volcano plot depicting transcriptomics data with dotted line marking P = 0.05 on y-axis and fold change of greater than 1 on X-axis. The top ten gene names are shown (red: upregulated, blue: downregulated). B Gene Ontology analyses of RNA-seq data showed significant changes in pathways in the ileum from the control and iNOS−/− groups. C Kyoto Encyclopedia of Genes and Genomes enrichment analysis (upregulated and downregulated differential) bubble plot. The X-axis is the enrichment score, and the y-axis is the pathway information of the top 20. The larger the bubble, the greater the number of differential proteins contained in the entry. When the color of bubbles changes from red to yellow and blue, the p value decreases. D GSEA of genes upregulated or downregulated in association with iNOS depletion