Fig. 3

Knockdown of MAD2L2 inhibits the proliferation, migration, and invasive abilities of glioma cells. A, B Expression levels of MAD2L2 in various cell lines. C, D, F CCK8, colony formation assay and EDU assay indicated that knockdown of MAD2L2 inhibited the proliferation of U87 and A172 cells. E Flow cytometry analysis indicated that MAD2L2 silencing decelerated the G1-S cell cycle transition. G, H Scratch assay and “Transwell” assay demonstrated the decrease in cell migration and invasion capabilities after MAD2L2 knockdown. *P < 0.05, **P < 0.01, ***P < 0.001