Fig. 2

High expression of MAD2L2 is associated with poor prognosis. A KM survival curves from four cohorts consistently indicate that the median survival time of the MAD2L2 high-expression group is lower than that of the low-expression group. B Univariate cox regression analysis reveals that MAD2L2 is a prognostic risk factor. C A nomogram was constructed based on MAD2L2 group, IDH mutation status, 1p19q codeletion status, tumor grades, and age D–E index and ROC curve of the nomogram. F Single-cell sequencing data from TISCH involving 17 groups of glioma show that the median expression value of MAD2L2 is highest in malignant cells. G The bubble plot illustrates that MAD2L2 is positively correlated with cell cycle, proliferation, and stemness pathway scores in glioma. H UMAP shows different cell states in glioma tissue. I, J The expression distribution and relative expression level of MAD2L2