TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study

Table 1 Coloc results for TIE1 or TEK signalling and IOP

Drug Target	p12	PP_distinct	PP_shared	PP_shared/(PP_distinct + PP_shared)
TIE1 signalling	1 × 10^–5	0.002	0.10	0.98
TIE1 signalling	5 × 10^–5	0.001	0.37	0.98
TEK signalling	1 × 10^–5	0.25	0.11	0.30
TEK signalling	5 × 10^–5	0.18	0.37	0.68

Coloc results. PP_distinct: Posterior probability of a distinct causal variant for TIE1/TEK and IOP (PP_distinct); PP_shared: Posterior probability of a shared causal variant for TIE1/TEK and IOP; PP_shared /(PP_distinct + PP_shared): Posterior probability of a shared causal variant for TIE1/TEK and IOP conditional on the presence of one or more causal variants (PP_shared/PP_shared + PP_distinct). Results are reported for two prior probabilities of a shared causal variant for TIE1/TEK and IOP (p12): p12 = 1 × 10^–5 and 5 × 10^–5

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