Table 3 Response over time
All patients, n [%], (95% CIa) | Day 28 | Day 60 | Day 180 |
|---|---|---|---|
N = 156 | N = 155 | N = 147 | |
Overall responseb | 77 [49.4%] (41.3%, 57.5%) | 76 [49.0%] (40.9%, 57.2%) | 58 [39.5%] (31.5%, 47.8%) |
Complete response | 21 [13.5%] (8.5%, 19.8%) | 41 [26.5%] (19.7%, 34.1%) | 45 [30.6%] (23.3%, 38.7%) |
Partial response | 56 [35.9%] (28.4%, 44.0%) | 35 [22.6%] (16.3%, 30.0%) | 13 [8.8%] (4.8%, 14.6%) |
Very good partial response | 22 [14.1%] (9.1%, 20.6%) | 12 [7.7%] (4.1%, 13.1%) | 5 [3.4%] (1.1%, 7.8%) |
Other partial response | 34 [21.8%] (15.6%, 29.1%) | 23 [14.8%] (9.6%, 21.4%) | 8 [5.4%] (2.4%, 10.4%) |
No response | 79 [50.6%] (42.5%, 58.7%) | 79 [51.0%] (42.8%, 59.1%) | 89 [60.5%] (52.2%, 68.5%) |
Children/adolescents, n[%], (95% CIa) | Day 28 | Day 60 | Day 180 |
|---|---|---|---|
n = 33 | n = 33 | n = 30 | |
Overall responseb | 21 [63.6%] (45.1%, 79.6%) | 17 [51.5%] (33.5%, 69.2%) | 14 [46.7%] (28.3%, 65.7%) |
Complete response | 3 [9.1%] (1.9%, 24.3%) | 11 [33.3%] (18.0%, 51.8%) | 11 [36.7%] (19.9%, 56.1%) |
Partial response | 18 [54.5%] (36.4%, 71.9%) | 6 [18.2%] (7.0%, 35.5%) | 3 [10.0%] (2.1%, 26.5%) |
Very good partial response | 5 [15.2%] (5.1%, 31.9%) | 3 [9.1%] (1.9%, 24.3%) | 1 [3.3%] (0.1%, 17.2%) |
Other partial response | 13 [39.4%] (22.9%, 57.9%) | 3 [9.1%] (1.9%, 24.3%) | 2 [6.7%] (0.8%, 22.1%) |
No response | 12 [36.4%] (20.4%, 54.9%) | 16 [48.5%] (30.8%, 66.5%) | 16 [53.3%] (34.3%, 71.7%) |
Adults, n[%], (95% CIa) | Day 28 | Day 60 | Day 180 |
|---|---|---|---|
n = 123 | n = 122 | n = 117 | |
Overall responseb | 56 [45.5%] (36.5%, 54.8%) | 59 [48.4%] (39.2%, 57.6%) | 44 [37.6%] (28.8%, 47.0%) |
Complete response | 18 [14.6%] (8.9%, 22.1%) | 30 [24.6%] (17.2%, 33.2%) | 34 [29.1%] (21.0%, 38.2%) |
Partial response | 38 [30.9%] (22.9%, 39.9%) | 29 [23.8%] (16.5%, 32.3%) | 10 [8.5%] (4.2%, 15.2%) |
Very good partial response | 17 [13.8%] (8.3%, 21.2%) | 9 [7.4%] (3.4%, 13.5%) | 4 [3.4%] (0.9%, 8.5%) |
Other partial response | 21 [17.1%] (10.9%, 24.9%) | 20 [16.4%] (10.3%, 24.2%) | 6 [5.1%] (1.9%, 10.8%) |
No response | 67 [54.5%] (45.2%, 63.5%) | 63 [51.6%] (42.4%, 60.8%) | 73 [62.4%] (53.0%, 71.2%) |