Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study

Wang, Xin; Ma, Rui; Shi, Rongcan; Qin, Hui; Chen, Wenjuan; Yu, Zengyang; Ding, Yangfeng; Peng, Chen; Shi, Yuling

doi:10.1186/s12967-023-04726-y

Table 4 Association between plasma PUFAs and psoriasis severity in females

From: Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study

PUFAs (mol %)	PASI (n = 68)		BSA (n = 68)		PGA (n = 68)		PtGA (n = 64)		DLQI (n = 64)
PUFAs (mol %)	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
Omega-3
α-Linolenic acid (18:3n3)	0.31 (− 0.95, 1.57)	0.635	0.65 (− 1.86, 3.16)	0.610	− 0.01 (− 0.19, 0.16)	0.883	0.10 (− 0.45, 0.66)	0.717	− 0.36 (− 2.07, 1.34)	0.675
Eicosapentaenoic acid (20:5n3)	− 2.67 (− 5.21, − 0.14)	0.039	− 5.84 (− 10.86, − 0.81)	0.023	0.27 (− 0.09, 0.63)	0.144	− 0.99 (− 2.08, 0.10)	0.074	− 2.91 (− 6.26, 0.43)	0.088
Docosahexaenoic acid (22:6n3)	− 0.92 (− 1.72, − 0.12)	0.024	− 2.02 (− 3.61, − 0.44)	0.011	0.04 (− 0.07, 0.16)	0.449	− 0.19 (− 0.55, 0.17)	0.297	− 0.85 (− 1.94, 0.24)	0.127
Omega-3 PUFAs	− 0.65 (− 1.28, − 0.02)	0.045	− 1.42 (− 2.67, − 0.17)	0.023	0.04 (− 0.05, 0.13)	0.383	− 0.15 (− 0.43, 0.13)	0.288	− 0.78 (− 1.61, 0.06)	0.068
Omega-6
Linoleic acid (18:2n6-cis)	0.27 (− 0.18, 0.72)	0.243	0.84 (− 0.05, 1.73)	0.063	− 0.02 (− 0.08, 0.05)	0.581	0.12 (− 0.08, 0.32)	0.246	− 0.24 (− 0.86, 0.38)	0.447
Eicosadienoic acid (20:2n6)	5.41 (− 4.84, 15.66)	0.301	6.37 (− 14.20, 26.95)	0.544	1.02 (− 0.41, 2.45)	0.161	3.06 (− 1.37, 7.50)	0.176	1.67 (− 12.08, 15.42)	0.812
Dohomo-γ-linolenic acid (20:3n6)	− 12.40 (− 62.94, 38.14)	0.631	− 29.57 (− 130.28, 71.13)	0.565	4.17 (− 2.85, 11.19)	0.245	− 4.19 (− 26.40, 18.02)	0.711	27.32 (− 40.68, 95.32)	0.431
Arachidonic acid (20:4n6)	− 0.09 (− 0.50, 0.31)	0.644	− 0.26 (− 1.06, 0.54)	0.523	− 0.03 (− 0.08, 0.03)	0.382	− 0.05 (− 0.22, 0.13)	0.598	− 0.27 (− 0.79, 0.26)	0.318
Omega-6 PUFAs	0.08 (− 0.25, 0.41)	0.628	0.27 (− 0.39, 0.92)	0.424	− 0.02 (− 0.07, 0.02)	0.286	0.03 (− 0.11, 0.18)	0.672	− 0.32 (− 0.76, 0.13)	0.163
Omega-6/3 ratio	0.76 (− 0.14, 1.67)	0.082	1.80 (0.01, 3.59)	0.049	− 0.08 (− 0.20, 0.05)	0.244	0.25 (− 0.14, 0.65)	0.210	0.86 (− 0.36, 2.07)	0.166

Data in bold significant
PUFAs were expressed as molar proportions (mol %) of total fatty acids. The regression coefficients were adjusted for age, education (high school or lower, college or above), smoking history, and alcohol use history
β β-coefficient, BSA Body Surface Area, CI confidence interval, DLQI Dermatology Life Quality Index, PASI Psoriasis Area and Severity Index, PGA Physician Global Assessment, PtGA Patient Global Assessment, PUFAs polyunsaturated fatty acids

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