Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study

Wang, Xin; Ma, Rui; Shi, Rongcan; Qin, Hui; Chen, Wenjuan; Yu, Zengyang; Ding, Yangfeng; Peng, Chen; Shi, Yuling

doi:10.1186/s12967-023-04726-y

Table 3 Association between plasma PUFAs levels and psoriasis severity in males

From: Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study

PUFAs (mol %)	PASI (n = 228)		BSA (n = 227)		PGA (n = 228)		PtGA (n = 213)		DLQI (n = 216)
PUFAs (mol %)	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
Omega-3
α-Linolenic acid (18:3n3)	− 0.46 (− 1.20, 0.28)	0.220	− 0.83 (− 2.46, 0.80)	0.318	0.00 (− 0.07. 0.08)	0.917	− 0.02 (− 0.25, 0.21)	0.866	1.20 (0.52, 1.89)	0.0005
Eicosapentaenoic acid (20:5n3)	0.78 (-0.82, 2.37)	0.340	1.45 (− 2.06, 4.96)	0.418	− 0.08 (− 0.23, 0.08)	0.315	− 0.12 (− 0.62, 0.37)	0.630	− 0.67 (− 2.16, 0.82)	0.375
Docosahexaenoic acid (22:6n3)	0.48 (− 0.16, 1.13)	0.144	0.91 (− 0.52, 2.33)	0.211	− 0.00 (− 0.07, 0.06)	0.916	0.03 (− 0.17, 0.23)	0.780	− 0.11 (− 0.72, 0.50)	0.731
Omega-3 PUFAs	0.13 (− 0.29, 0.55)	0.544	0.24 (− 0.74, 1.22)	0.630	− 0.01 (− 0.05, 0.04)	0.773	− 0.00 (− 0.14, 0.13)	0.967	0.33 (− 0.09, 0.75)	0.123
Omega-6
Linoleic acid (18:2n6-cis)	− 0.06 (− 0.37, 0.25)	0.695	− 0.34 (− 1.02, 0.35)	0.337	0.01 (− 0.02, 0.04)	0.575	− 0.00 (− 0.10, 0.09)	0.953	0.25 (− 0.05, 0.54)	0.097
Eicosadienoic acid (20:2n6)	7.10 (0.61, 13.60)	0.032	14.90 (0.56, 29.24)	0.042	0.88 (0.26, 1.51)	0.0058	1.34 (− 0.67, 3.35)	0.190	1.08 (− 5.13, 7.28)	0.734
Dohomo-γ-linolenic acid (20:3n6)	36.96 (− 6.15, 80.06)	0.093	71.81 (− 23.26, 166.88)	0.139	1.91 (− 2.31, 6.13)	0.375	− 2.50 (− 15.68, 10.67)	0.710	3.73 (− 37.16, 44.63)	0.858
Arachidonic acid (20:4n6)	0.12 (− 0.13, 0.36)	0.360	0.08 (− 0.47, 0.63)	0.773	0.00 (− 0.02, 0.03)	0.771	− 0.01 (− 0.09, 0.07)	0.792	− 0.35 (− 0.58, − 0.11)	0.0039
Omega-6 PUFAs	0.07 (− 0.15, 0.29)	0.536	− 0.09 (− 0.58, 0.40)	0.726	0.01 (− 0.01, 0.03)	0.448	− 0.01 (− 0.08, 0.06)	0.814	− 0.14 (− 0.35, 0.07)	0.193
Omega-6/3 ratio	0.12 (− 0.32, 0.56)	0.597	− 0.00 (− 1.30, 1.29)	0.997	0.02 (− 0.03, 0.08)	0.421	0.02 (− 0.17, 0.21)	0.836	− 0.49 (− 1.07, 0.09)	0.095

Data in bold significant
PUFAs were expressed as molar proportions (mol %) of total fatty acids. The regression coefficients were adjusted for age, education (high school or lower, college or above), smoking history, and alcohol use history
β β-coefficient, BSA Body Surface Area, CI confidence interval, DLQI Dermatology Life Quality Index, PASI Psoriasis Area and Severity Index, PGA Physician Global Assessment, PtGA Patient Global Assessment, PUFAs polyunsaturated fatty acids

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