Fig. 1

Select RNA modification regulators and glioma survival. A Kaplan–Meier curves shown for RNA B modification regulators YTHDF2, NSUN4, PUS7, WTAP, and ADAR3. Note both IDH wildtype and mutant status are included. GlioVis data portal for visualization and analysis of brain tumor expression datasets [123]. B PDB images of each protein or protein complex [131] is shown adjacent to the respective modification involved. Of note, YTHDF2 has been shown to be a reader molecule for both m1A and m6A [124, 125]. C mRNA modifications are shown in the most probable area based on its respective transcriptome-wide distribution [8]. CDS, coding sequence; UTR, untranslated region