Fig. 1
From: TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
TC2N expression is related to tumor metastasis and differentiation status of BC patients. A The protein expression of TC2N was detected by IHC staining in BC tissues. High TC2N expression group contains the ≥ 3 score patients. Low TC2N expression group contains the < 3 score patients. Scale bars represent 20 μm. B TC2N expression was significantly decreased in advanced-stage BC patients than that in early-stage BC patients. The P value was measured with Student’s t-tests. *P < 0.05; **P < 0.01; ***P < 0.001. C TC2N expression was obviously decreased in BC patients with lymph node metastasis (N1–3) than that without lymph node metastasis (N0). The P value was measured with Student’s t-tests. ***P < 0.001. D TC2N expression was significantly decreased in BC patients with distant-metastasis (M1) than that without metastasis (M0). The P value was measured with Student’s t-tests. ***P < 0.001. Scale bars represent 20 μm. E The expression of TC2N in different metastatic sites. The P value was measured with Student’s t-tests. ns, no significance. F TC2N expression in BC tissues at different differentiating degree. The P value was measured with Student’s t-tests. ns, no significance, *P < 0.05. G TCGA BC database identified the association between TC2N expression and metastasis and differentiation-related processes. H CPTAC BC protein dataset identified the association between TC2N expression and metastasis and differentiation-related processes. I Kaplan–Meier analysis of the correlation between TC2N expression and overall survival time in 212 BC patients. J Cox-regression analysis of the correlation between TC2N expression and overall survival time in 212 BC patients