Fig. 9

Upregulated circFGFR1^int2 and downregulated miR-4687-5p promoted PCa cell proliferation, migration, and invasion. A–C Knockdown of circFGFR1^int2 by ASO-circFGFR1^int2 or artificial overexpression of miR-4687-5p by mimic significantly decreased PCa cell proliferation and DNA replication as shown by CCK-8 assays and EdU incorporation assays, which could be reversed by artificial overexpression of circFGFR1^int2. D Knockdown of circFGFR1^int2 by ASO-circFGFR1^int2 or artificial overexpression of miR-4687-5p by mimic significantly decreased PCa cell migration and invasion as shown by wound healing, which could be reversed by artificial overexpression of circFGFR1^int2. E Similar effects as shown by Transwell assays. Three microscopic fields were evaluated for each sample. Error bars for CCK-8, EdU incorporation, wound healing and Transwell assays represented mean ± standard deviation (SD) of three independent experiments. **P < 0.01, ***P < 0.001